PSEM 89S TFA is primarily utilized in neuroscience research as a selective and potent agonist for GABA_B receptors in the brain. It is commonly employed in studies aimed at understanding receptor signaling pathways and their roles in neurological functions. Researchers use it to investigate synaptic activity, neuronal communication, and potential therapeutic targets for neurological disorders. Its application extends to in vitro and in vivo experiments, where it helps elucidate the effects of receptor activation on behavior, cognition, and disease mechanisms. Additionally, it serves as a valuable tool in the development of novel pharmacological interventions for conditions such as anxiety, depression, and neurodegenerative diseases.