Nor-binaltorphimine dihydrochloride is a potent and selective antagonist for the kappa opioid receptor (KOR). It is primarily used in neuroscience research to study the role of kappa opioid receptors in pain modulation, addiction, mood disorders, and stress responses. Due to its high selectivity, it helps researchers differentiate kappa receptor-mediated effects from those involving mu or delta opioid receptors.

This compound is widely used in preclinical studies to block kappa receptor activity, allowing investigation into the mechanisms of dysphoria, anxiety, and depression linked to KOR activation. It has also been employed in studies exploring substance abuse, particularly in models involving cocaine, alcohol, and opioids, where KOR systems influence relapse and reward pathways.

In pain research, nor-binaltorphimine dihydrochloride is used to examine the long-term effects of KOR antagonism on chronic and neuropathic pain, showing potential for developing new analgesic strategies. Its long duration of action in vivo makes it especially useful for experiments requiring sustained receptor blockade.

Overall, this chemical is a critical tool in advancing understanding of the opioid system and developing treatments for psychiatric and neurological conditions.