WAY-606954 is primarily used in scientific research as a selective agonist for the GPR139 receptor, a G protein-coupled receptor expressed in the brain. Its main application lies in neuropharmacological studies, where it helps investigate the role of GPR139 in modulating neurotransmitter systems, particularly those involving dopamine and glutamate. Researchers use WAY-606954 to explore potential pathways related to psychiatric and neurological disorders such as schizophrenia, depression, and addiction. Due to its ability to cross the blood-brain barrier and elicit central nervous system responses in preclinical models, it serves as a valuable tool compound for validating GPR139 as a therapeutic target. It is not used clinically and remains restricted to laboratory and experimental settings.