WAY-639549 is primarily used in scientific research as a potent and selective agonist for the GPR139 receptor, a G-protein-coupled receptor expressed in specific regions of the brain. Its main application lies in neuroscience studies aimed at understanding the role of GPR139 in modulating neurotransmitter systems, particularly those involving dopamine and glutamate. Researchers use WAY-639549 to probe the receptor’s involvement in behavioral models related to mood disorders, addiction, and cognitive function. Due to its selectivity, it serves as a valuable pharmacological tool for validating GPR139 as a potential therapeutic target in psychiatric and neurological conditions. It is not used clinically and remains restricted to in vitro and in vivo experimental settings.