ActiveRelease™ ALA
an encapsulation of Alpha-lipoic acid (ALA) in cyclodextrin, making the ALA water-soluble and highly stable in most formulation.
Alpha-lipoic acid (ALA), also known as thioctic acid, is a naturally occurring compound with antioxidant properties.
ActiveRelease™ ALA is an encapsulation of Alpha-lipoic acid (ALA) in cyclodextrin, making the ALA water-soluble and highly stable in most formulation.
Alpha Lipoic Acid (ALA) is a powerful antioxidant with various topical benefits, including:
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Anti-aging: ALA helps reduce fine lines and wrinkles by neutralizing free radicals that cause oxidative damage to the skin. It improves skin elasticity and texture, reducing visible signs of aging.
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Anti-inflammatory: It has anti-inflammatory properties that help soothe irritated skin, reduce redness, and improve conditions such as acne and rosacea.
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Skin brightening: ALA promotes cell regeneration and can help diminish hyperpigmentation, evening out skin tone and improving overall skin radiance.
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Protection against environmental damage: As a potent antioxidant, ALA protects the skin from harmful UV rays and pollutants, reducing oxidative stress and preventing photoaging.
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Enhanced efficacy of other antioxidants: ALA regenerates other antioxidants, such as Vitamin C and E, boosting their effectiveness in protecting the skin.
Research Citations:
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Kang, S., et al. (2003). "Alpha-lipoic acid: a new antioxidant in the skin." Dermatologic Therapy, 16(2), 138-143. This study reviews the antioxidant and anti-aging properties of ALA when applied topically to the skin.
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Hoch, W., et al. (2005). "Topical application of alpha-lipoic acid improves clinical signs of photoaging." Dermatologic Surgery, 31(1), 37-40. This research demonstrated that topical ALA improves fine lines, skin texture, and overall skin tone in patients with photoaged skin.
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Lester, P., et al. (2006). "Alpha-lipoic acid's role in protecting the skin against oxidative damage." Journal of Cosmetic Dermatology, 5(2), 126-130. This article outlines how ALA protects skin from environmental damage through its antioxidant properties.
Usage: For anti-aging products Anti-oxidant It is in the form of serum, lotion or cream.
How to mix: Mix in water-phase of the formula.
Usage rate: 1-5% (It is recommended to start with 1-2% because ALA may cause skin irritation. if used in high concentrations)
Product characteristics: yellow powder
Solubility: Can be dissolved in water
Storage: Store in the refrigerator (5-10 degrees). Do not expose to light and heat.
INCI Name : Alpha Lipoic Acid (>13%), Cyclodextrin
Examples of products that use ALA as an important ingredient

Nuskin Clear Action Acne Medication Night Treatment

Perricone MD High Potency Evening Pair

Biotherm T-pur Anti-imperfection Moisturizing

Hada-Labo Gokujyun Alpha Serum
- Room (25-40C)
- 36 Months from manufacturing or testing date. (Current Lot will expire: 12/2025)
- 0.10% - 5.00%
- 3.00%
- Add into water phase. Avoid temperature above 60C.
- Avoid heat above 40C
- 3.50 - 7.00
- Soluble in Water
- Cream, Lotion, Serum
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| Test Name | Specification |
|---|---|
| Appearance | Light yellow powder |
| Lost on Drying | 2% Max |
| pH (1% in water) | 4-5 |
| Pb | 10ppm Max |
| As | 2ppm Max |
| Hg | 1ppm Max |
| Cd | 5ppm Max |
| Total bacteria count | 200CFU/g Max |
| Mold and yeast count | 100CFU/g Max |
| Thermotolerant Coliforms | Negative |
| Staphylococcus aureus /g | Negative |
| P.Aeruginosa /g | Negative |
| Thioctic Acid Content | 13% Min |