JSH-23 is primarily used in research settings to study the NF-κB signaling pathway, which plays a critical role in inflammation, immune response, and cell survival. It is a selective inhibitor of NF-κB activation, making it a valuable tool for understanding the molecular mechanisms underlying diseases such as cancer, autoimmune disorders, and chronic inflammatory conditions. Researchers use JSH-23 to investigate how blocking NF-κB affects cellular processes, including apoptosis, cytokine production, and tumor progression. Its application extends to preclinical studies aimed at developing therapeutic strategies targeting NF-κB-related pathways.