MK-8033 is primarily used in research settings as a potent and selective antagonist for the NMDA receptor, specifically targeting the NR2B subunit. Its application is significant in neuroscience studies, where it helps in understanding the role of NMDA receptors in synaptic plasticity, learning, and memory processes. Researchers utilize MK-8033 to investigate its potential neuroprotective effects, particularly in conditions like stroke, traumatic brain injury, and neurodegenerative diseases such as Alzheimer's. Additionally, it is employed in studies exploring the mechanisms of chronic pain and psychiatric disorders, providing insights into the development of therapeutic strategies targeting NMDA receptor dysfunction.