Ro 25-6981 Maleate is primarily used in neuroscience research as a selective and potent antagonist of the NMDA receptor, specifically targeting the NR2B subunit. Its application is significant in studying the role of NMDA receptors in synaptic plasticity, learning, and memory processes. Researchers utilize it to investigate neurological disorders such as Alzheimer's disease, Parkinson's disease, and chronic pain, as it helps in understanding the mechanisms underlying these conditions. Additionally, it is employed in experimental models to explore its potential neuroprotective effects and its role in modulating excitotoxicity, which is implicated in stroke and other brain injuries.