GW 9578 is primarily utilized in research settings to study the mechanisms and effects of peroxisome proliferator-activated receptor (PPAR) activation. It serves as a potent and selective agonist for PPARδ, a nuclear receptor involved in regulating genes associated with lipid metabolism and energy homeostasis. Researchers employ GW 9578 to investigate its potential role in enhancing fatty acid oxidation, improving insulin sensitivity, and influencing metabolic disorders such as obesity and type 2 diabetes. Additionally, it is used to explore its effects on skeletal muscle function and endurance, as PPARδ activation has been linked to increased oxidative capacity in muscle cells. GW 9578 is also a valuable tool in understanding the broader physiological roles of PPARδ in inflammation, cellular differentiation, and cardiovascular health. Its application extends to preclinical studies aiming to develop therapeutic strategies for metabolic and inflammatory diseases.