Nuclease micrococcal from Staphylococcus aureus is widely used in molecular biology for its ability to degrade nucleic acids. It is particularly valuable in the preparation of DNA-free RNA samples, ensuring accurate results in RNA analysis. The enzyme is also employed in chromatin immunoprecipitation (ChIP) assays to digest unprotected DNA, aiding in the study of protein-DNA interactions. Additionally, it is utilized in cell lysis protocols to eliminate nucleic acids, reducing viscosity and improving protein purification efficiency. Its application extends to the removal of DNA contamination in vaccine production, ensuring the safety and efficacy of biological products.