1-((2R, 3R, 4R, 5R)-4-((tert-Butyldimethylsilyl)oxy)-5-(((tert-butyldimethylsilyl)oxy)methyl)-3-methoxytetrahydrofuran-2-yl)-4-(1H-1, 2, 4-triazol-1-yl)pyrimidin-2(1H)-one
97%
Reagent
Code: #231125
CAS Number
1428902-86-6
science Other reagents with same CAS 1428902-86-6
blur_circular Chemical Specifications
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Molecular Information
Weight
537.80 g/mol
Formula
C₂₄H₄₃N₅O₅Si₂
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Registry Numbers
MDL Number
MFCD34596685
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Storage & Handling
Storage
2-8°C, dry, light-proof
description Product Description
Used as an intermediate in the synthesis of antiviral agents, particularly in the preparation of nucleoside analogs targeting RNA viruses such as SARS-CoV-2 and Ebola. Its protected functional groups, including tert-butyldimethylsilyl (TBDMS) moieties, allow selective reactions during multi-step synthesis, making it valuable in developing pharmaceuticals. Commonly employed in the production of remdesivir and related compounds due to its ability to mimic natural nucleosides, thereby inhibiting viral RNA-dependent RNA polymerase and replication.
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