Used in solid-phase oligonucleotide synthesis, this specialized non-nucleosidic phosphoramidite reagent enables the efficient incorporation of a modified linker with a chromophoric azo dye moiety into DNA or RNA strands. Its structure includes a protected 2-(bis(4-methoxyphenyl)(phenyl)methoxy)ethyl group for stepwise deprotection and a 4-(substituted diazenyl)phenylaminoethyl group featuring light-sensitive azo linkages and electron-withdrawing nitro substituents, which support the addition of functional groups enhancing detection, stability, and binding specificity. This makes it valuable in developing labeled probes for diagnostics, antisense therapies, PCR primers, and assays in genetic research and drug discovery. The 2-cyanoethyl and diisopropylphosphoramidite functionalities ensure controlled coupling and high yield/purity in automated synthesis, aiding creation of tailored nucleic acids with improved nuclease resistance and target affinity.