Used in the synthesis of modified oligonucleotides for research and therapeutic applications, particularly in enhancing the stability and cellular uptake of nucleic acid constructs. Its cholesterol derivative enables efficient lipid conjugation, making it valuable in developing antisense, siRNA, and diagnostic probes where improved pharmacokinetics and membrane targeting are required. Commonly employed in solid-phase oligonucleotide synthesis due to its compatibility with standard phosphoramidite chemistry.