3'-O-tert-Butyldimethylsilyl-5'-O-DMT-uridine

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Reagent Code: #97170
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CAS Number 81246-81-3

science Other reagents with same CAS 81246-81-3

blur_circular Chemical Specifications

scatter_plot Molecular Information
Weight 660.83 g/mol
Formula C₃₆H₄₄N₂O₈Si
inventory_2 Storage & Handling
Storage 2-8°C

description Product Description

This chemical is primarily used in the synthesis of oligonucleotides, particularly in the field of molecular biology and genetic research. It serves as a protected nucleoside, where the tert-butyldimethylsilyl (TBDMS) group shields the 3'-hydroxyl position and the dimethoxytrityl (DMT) group protects the 5'-hydroxyl position. These protective groups are crucial during the stepwise assembly of DNA or RNA strands, ensuring that reactions occur selectively at the desired sites. The compound is especially valuable in solid-phase oligonucleotide synthesis, where it allows for the precise construction of sequences used in applications such as PCR, gene editing, and antisense therapy. Its stability and ease of deprotection make it a reliable building block in the production of custom nucleic acids for research and therapeutic purposes.

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Size Availability Unit Price Quantity
inventory 1g
10-20 days ฿8,271.00
inventory 250mg
10-20 days ฿3,186.00

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3'-O-tert-Butyldimethylsilyl-5'-O-DMT-uridine
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This chemical is primarily used in the synthesis of oligonucleotides, particularly in the field of molecular biology and genetic research. It serves as a protected nucleoside, where the tert-butyldimethylsilyl (TBDMS) group shields the 3'-hydroxyl position and the dimethoxytrityl (DMT) group protects the 5'-hydroxyl position. These protective groups are crucial during the stepwise assembly of DNA or RNA strands, ensuring that reactions occur selectively at the desired sites. The compound is especially va

This chemical is primarily used in the synthesis of oligonucleotides, particularly in the field of molecular biology and genetic research. It serves as a protected nucleoside, where the tert-butyldimethylsilyl (TBDMS) group shields the 3'-hydroxyl position and the dimethoxytrityl (DMT) group protects the 5'-hydroxyl position. These protective groups are crucial during the stepwise assembly of DNA or RNA strands, ensuring that reactions occur selectively at the desired sites. The compound is especially valuable in solid-phase oligonucleotide synthesis, where it allows for the precise construction of sequences used in applications such as PCR, gene editing, and antisense therapy. Its stability and ease of deprotection make it a reliable building block in the production of custom nucleic acids for research and therapeutic purposes.

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