hDHODH-IN-3 is primarily used in research and development as a potent inhibitor of human dihydroorotate dehydrogenase (hDHODH). This enzyme plays a critical role in the de novo pyrimidine biosynthesis pathway, which is essential for DNA and RNA synthesis. By inhibiting hDHODH, this compound is studied for its potential therapeutic applications in treating diseases characterized by excessive cell proliferation, such as autoimmune disorders and certain types of cancer. Researchers are particularly interested in its ability to suppress immune cell activation, making it a promising candidate for conditions like rheumatoid arthritis, multiple sclerosis, and transplant rejection. Additionally, its role in disrupting pyrimidine synthesis is being explored in antiviral research, as viruses rely heavily on host cell machinery for replication. hDHODH-IN-3 is also utilized in preclinical studies to better understand the mechanisms of hDHODH inhibition and its broader implications in cellular metabolism and disease progression.