Adenosine 5'-(γ-thio)-triphosphate (lithium salt) (ATPγS)

98%

Reagent Code: #107526
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CAS Number 93839-89-5

blur_circular Chemical Specifications

scatter_plot Molecular Information
Weight 546.98 g/mol
Formula C₁₀H₁₂N₅O₁₂P₃S₄Li
inventory_2 Storage & Handling
Storage -20°C, airtight, dry

description Product Description

ATPγS is widely used in biochemical research as a non-hydrolyzable analog of ATP, making it valuable for studying ATP-dependent processes. It is particularly useful in kinase assays, where it serves as a substrate to investigate enzyme activity without being broken down. This property allows researchers to trap and analyze intermediate states of enzymatic reactions. Additionally, ATPγS is employed in studying G-protein-coupled receptor signaling pathways, as it can activate G-proteins without subsequent deactivation. It is also used in protein phosphorylation studies to create thiophosphorylated proteins, which are resistant to phosphatases, enabling the examination of phosphorylation effects over extended periods. In structural biology, ATPγS aids in stabilizing protein complexes for X-ray crystallography or cryo-EM analysis. Its applications extend to investigating nucleotide-binding proteins, ion channels, and cellular energy metabolism.

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Test Parameter Specification
Appearance White Powder
Purity (%) 97.5-100%
Infrared Spectrum Conforms to Structure
NMR Conforms To Structure

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Size Availability Unit Price Quantity
inventory 5mg
10-20 days ฿23,860.00
inventory 10mg
10-20 days ฿43,800.00
Adenosine 5'-(γ-thio)-triphosphate (lithium salt) (ATPγS)
ATPγS is widely used in biochemical research as a non-hydrolyzable analog of ATP, making it valuable for studying ATP-dependent processes. It is particularly useful in kinase assays, where it serves as a substrate to investigate enzyme activity without being broken down. This property allows researchers to trap and analyze intermediate states of enzymatic reactions. Additionally, ATPγS is employed in studying G-protein-coupled receptor signaling pathways, as it can activate G-proteins without subsequent deactivation. It is also used in protein phosphorylation studies to create thiophosphorylated proteins, which are resistant to phosphatases, enabling the examination of phosphorylation effects over extended periods. In structural biology, ATPγS aids in stabilizing protein complexes for X-ray crystallography or cryo-EM analysis. Its applications extend to investigating nucleotide-binding proteins, ion channels, and cellular energy metabolism.
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