JDTic dihydrochloride is primarily used in research to study the kappa opioid receptor (KOR) system. It acts as a selective antagonist, blocking the effects of kappa opioid agonists, which makes it valuable for investigating the role of KOR in various physiological and behavioral processes. Researchers utilize it to explore its potential in addressing addiction, depression, and anxiety, as KOR modulation has been linked to these conditions. Additionally, it aids in understanding pain pathways and stress responses, providing insights into the development of novel therapeutic strategies. Its application is limited to preclinical studies, focusing on its pharmacological properties and mechanisms of action.