Oliceridine is primarily used in the management of acute severe pain in clinical settings, particularly for patients who require intravenous opioid analgesia. It is often administered in hospitals for postoperative pain relief, offering a rapid onset of action and effective pain control. Due to its selective mechanism of action on the mu-opioid receptor, it provides potent analgesia with potentially fewer side effects compared to traditional opioids, such as reduced respiratory depression and gastrointestinal issues. This makes it a valuable option for patients who may not tolerate conventional opioids well. Its use is typically monitored closely by healthcare professionals to ensure safety and efficacy.