Simethicone (USP44)
- Product Code: 35272
Simethicone is a medication used primarily to relieve the symptoms of gas in the stomach and intestines
Restricted product - require special permission
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| Test Name | Specification |
|---|---|
| Appearance | Clear to translucid gray liquid, viscous and free of dark particles |
| Solubility | The liquid phase is soluble in chloroform and ether, but the silicone dioxide may remains as a residue in these solvents, insolu |
| Identification | IR absorption spectrum of the sample shows absorption maxima only at the same wavelength and with the same relative intensities |
| Antifoaming activity | NMT 15 seconds |
| Loss on drying | NMT 18.0% |
| Heavy metals | NMT 5ppm |
| Silicone Dioxide Content | 4.0-7.0% |
| Assay | 90.5 - 99.0% of Polydimethylsiloxane |
| Total bacteria count | 100CFU/ml Max |
| Total fungi and yeast count | 10CFU/ml Max |
| E.Coli | Absent |
| Staphylococcus aureus | Absent |
| Pseudomonas aeruginosa | Absent |
(restricted sale - the buyer must be certified drug manufacturing facility)
Simethicone is a medication used primarily to relieve the symptoms of gas in the stomach and intestines, such as uncomfortable or painful pressure, fullness, and bloating. It is a nonabsorbable, surface-active agent that acts as an antifoaming agent, reducing the surface tension of gas bubbles, which allows them to coalesce and be expelled more easily from the body. Simethicone is available in various forms, including regular tablets, chewable tablets, capsules, and liquid, and is typically taken after meals and at bedtime[1][2][3].
Simethicone is considered safe for use in adults, children, and infants, with dosages adjusted according to age. For adults, the recommended dosage can range from 40 to 125 mg orally four times daily as needed, with a maximum daily dose of 500 mg. Children's dosages are adjusted based on their age group[5].
While simethicone is generally safe and usually has no side effects when taken as directed, it is important to follow the prescribed or recommended dosages and to consult a healthcare provider if there are any concerns or if symptoms persist. It is also advised to inform healthcare providers about any other medications being taken, as simethicone can be found in combination with other medications, and there may be considerations for interactions, although significant drug interactions with simethicone are minimal due to its lack of systemic absorption[1][5].
In clinical studies, simethicone has shown effectiveness in improving symptoms related to gas, such as heartburn, fullness, distension, and bloating, with significant improvement observed in patients taking simethicone compared to those taking a placebo[5].
Citations:
[1] https://medlineplus.gov/druginfo/meds/a682683.html
[2] https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/simethicone
[3] https://www.mayoclinic.org/drugs-supplements/simethicone-oral-route/description/drg-20068838
[4] https://www.drugs.com/mtm/simethicone.html
[5] https://www.ncbi.nlm.nih.gov/books/NBK555997/
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Simethicone (USP44)
Simethicone is a medication used primarily to relieve the symptoms of gas in the stomach and intestines
(restricted sale - the buyer must be certified drug manufacturing facility)
Simethicone is a medication used primarily to relieve the symptoms of gas in the stomach and intestines, such as uncomfortable or painful pressure, fullness, and bloating. It is a nonabsorbable, surface-active agent that acts as an antifoaming agent, reducing the surface tension of gas bubbles, which allows them to coalesce and be expelled more easily from the body. Simethicone is available in various forms, including regular tablets, chewable tablets, capsules, and liquid, and is typically taken after meals and at bedtime[1][2][3].
Simethicone is considered safe for use in adults, children, and infants, with dosages adjusted according to age. For adults, the recommended dosage can range from 40 to 125 mg orally four times daily as needed, with a maximum daily dose of 500 mg. Children's dosages are adjusted based on their age group[5].
While simethicone is generally safe and usually has no side effects when taken as directed, it is important to follow the prescribed or recommended dosages and to consult a healthcare provider if there are any concerns or if symptoms persist. It is also advised to inform healthcare providers about any other medications being taken, as simethicone can be found in combination with other medications, and there may be considerations for interactions, although significant drug interactions with simethicone are minimal due to its lack of systemic absorption[1][5].
In clinical studies, simethicone has shown effectiveness in improving symptoms related to gas, such as heartburn, fullness, distension, and bloating, with significant improvement observed in patients taking simethicone compared to those taking a placebo[5].
Citations:
[1] https://medlineplus.gov/druginfo/meds/a682683.html
[2] https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/simethicone
[3] https://www.mayoclinic.org/drugs-supplements/simethicone-oral-route/description/drg-20068838
[4] https://www.drugs.com/mtm/simethicone.html
[5] https://www.ncbi.nlm.nih.gov/books/NBK555997/
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