TCS-OX2-29 is primarily utilized in research settings, particularly in the field of neuroscience and pharmacology. It is known for its role as a selective antagonist for the orexin receptor type 2 (OX2R). This property makes it valuable in studies focused on understanding the orexin system, which is involved in regulating sleep-wake cycles, arousal, and energy balance. Researchers use TCS-OX2-29 to investigate the physiological and pathological roles of OX2R, including its implications in sleep disorders such as narcolepsy and insomnia. Additionally, it aids in exploring potential therapeutic targets for conditions linked to orexin receptor dysfunction. Its application is largely confined to preclinical studies, contributing to the development of novel drugs targeting the orexin pathway.