tert-Butyl(((3aR,4R,6aR)-5-fluoro-2,2-dimethyl-6-((trityloxy)methyl)-4,6a-dihydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)oxy)diphenylsilane
≥95%
Reagent
Code: #36054
CAS Number
805245-41-4
science Other reagents with same CAS 805245-41-4
blur_circular Chemical Specifications
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Molecular Information
Weight
684.91 g/mol
Formula
C₄₄H₄₅FO₄Si
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Registry Numbers
MDL Number
MFCD25977137
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Physical Properties
Boiling Point
681.5°C at 760 mmHg
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Storage & Handling
Storage
2-8°C, dry and sealed
description Product Description
This compound is a key synthetic intermediate in the development of fluorinated carbocyclic nucleoside analogs for antiviral and anticancer drugs. It possesses a stereodefined (3aR,4R,6aR)-5-fluoro-2,2-dimethyl-4,6a-dihydro-3aH-cyclopenta[d][1,3]dioxol-4-yl core, protected with a tert-butyldiphenylsilyloxy group and featuring a (trityloxy)methyl substituent at the 6-position. The orthogonal protecting groups—acetonide, trityl (Tr), and TBDPS—provide stability, selectivity, and precise deprotection control essential for constructing complex molecular architectures in medicinal chemistry.
format_list_bulleted Product Specification
| Test Parameter | Specification |
|---|---|
| Appearance | White to off-white solid |
| Purity | 94.5-100% |
| Infrared Spectrum | Conforms to Structure |
| NMR | Conforms to Structure |
| Appearance | White to off-white solid |
| Purity (%) | 94.5-100 |
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