Benzofuran-2-yltributylstannane is primarily used in organic synthesis as a key reagent in Stille coupling reactions. This process facilitates the formation of carbon-carbon bonds, particularly in the construction of complex organic molecules. Its application is significant in the synthesis of pharmaceuticals, where it helps create active compounds with precise structural configurations. Additionally, it is employed in the development of advanced materials, such as organic semiconductors and polymers, due to its ability to introduce benzofuran moieties into molecular frameworks. Its stability and reactivity make it a valuable tool in research and industrial chemistry for designing and producing specialized chemical products.