8-Hydroxy-2'-deoxyguanosine is widely used as a biomarker for oxidative stress and DNA damage in various biological and medical research studies. It helps in assessing the impact of environmental factors, lifestyle choices, and diseases on cellular health. In clinical settings, it aids in diagnosing conditions linked to oxidative damage, such as cancer, neurodegenerative disorders, and cardiovascular diseases. Additionally, it is utilized in pharmaceutical research to evaluate the efficacy of antioxidants and other therapeutic agents in mitigating oxidative stress. Its measurement in urine or blood samples provides valuable insights into the extent of DNA damage and the effectiveness of interventions aimed at reducing oxidative harm.