Corey 21 is widely used in organic synthesis as a powerful oxidizing agent, particularly for the selective oxidation of alcohols to carbonyl compounds. It enables high-yield transformations under mild conditions, making it valuable in the synthesis of complex natural products and pharmaceuticals. Its selectivity and efficiency are especially advantageous in multi-step reactions where functional group compatibility is critical. Additionally, Corey 21 is employed in research settings for method development in oxidation chemistry due to its reliable performance and predictable reactivity.