Widely used as a palladium-based catalyst in cross-coupling reactions, particularly in Suzuki-Miyaura and Buchwald-Hartwig aminations. Its bulky di-tert-butylphenylphosphine ligands enhance reactivity and stability, allowing efficient coupling of aryl chlorides, which are less reactive than bromides or iodides. This makes it cost-effective and practical for synthesizing complex organic molecules, especially in pharmaceutical and agrochemical industries. The catalyst promotes high yields under mild conditions and is effective with a broad substrate scope, including sterically hindered partners. It is also employed in the formation of carbon–nitrogen and carbon–carbon bonds in advanced intermediate synthesis.