PJ34 is primarily used in research settings to study the role of PARP (Poly ADP-Ribose Polymerase) enzymes in various cellular processes. It is a potent PARP inhibitor, making it valuable in experiments focused on understanding DNA repair mechanisms, particularly in the context of cancer research. By inhibiting PARP, PJ34 helps researchers explore how cells respond to DNA damage and the potential for inducing cell death in cancer cells, especially those with defective DNA repair pathways. Additionally, it is utilized in studies related to neurodegenerative diseases, ischemia, and inflammation, where PARP activity is implicated in cellular damage. Its application extends to preclinical models to evaluate therapeutic strategies targeting PARP-dependent pathways.