DSPE-MPEG2000 is widely used in the development of drug delivery systems, particularly in the creation of liposomes and micelles. Its amphiphilic nature allows it to stabilize these nanostructures, enhancing their circulation time in the bloodstream by reducing recognition and clearance by the immune system. This makes it a key component in targeted cancer therapies, where it helps deliver chemotherapeutic agents directly to tumor sites while minimizing systemic toxicity. Additionally, it is employed in the formulation of long-acting injectables and vaccines, improving the solubility and stability of active pharmaceutical ingredients. Its biocompatibility and ability to form stealth-like coatings on nanoparticles further expand its applications in biomedical research and therapeutic innovations.