Advanced cosmetic emulgel featuring 5% pharmaceutical-grade piperine from black pepper in a sophisticated delivery system. Clinically proven for vitiligo support, wound healing acceleration, and anti-inflammatory benefits. Acts as a powerful penetration enhancer, increasing skin permeation of co-formulated actives. Unique gel-cream texture with cyclodextrin complex ensures optimal bioavailability and stability.

Emulgel™ Piperine is an advanced cosmetic formulation featuring piperine, the bioactive alkaloid from black pepper (Piper nigrum), in a sophisticated emulgel delivery system. This innovative product combines 5% pharmaceutical-grade piperine with a carefully selected base of cyclodextrin, MCT oil, and glyceryl stearate emulsifiers to create a unique gel-like texture that enhances skin penetration and bioavailability.

Piperine has emerged as a remarkable cosmetic ingredient with multiple evidence-based benefits for skin health. Clinical studies have demonstrated its efficacy in promoting melanocyte stimulation and repigmentation, particularly when used as an adjunct to phototherapy for vitiligo treatment. A randomized controlled trial showed significantly greater repigmentation when 1% piperine cream was combined with narrowband UVB therapy compared to UV treatment alone. Beyond pigmentation support, piperine exhibits potent anti-inflammatory and antioxidant properties, modulating NF-κB and STAT3 pathways to reduce skin inflammation and protect against UV-induced damage.

The emulgel format represents an optimal delivery system for piperine, combining the advantages of both gels and emulsions. This unique texture ensures excellent spreadability while the inclusion of penetration enhancers like propylene glycol and cyclodextrin complexation technology maximizes piperine's bioavailability. Research has shown that piperine itself acts as a powerful penetration enhancer, increasing the skin permeation of co-formulated actives through mild lipid disruption and modification of the stratum corneum barrier function.

Usage: Apply a small amount to clean, dry skin once or twice daily. For vitiligo support, apply before UV therapy sessions, allowing 30-60 minutes between application and UV exposure to minimize photo-isomerization. For general anti-inflammatory benefits or as a penetration enhancer for other actives, massage gently into affected areas. Expect mild transient warmth upon application due to TRPV1 receptor activation. Discontinue use if persistent irritation occurs.

How to mix: This is a ready-to-use formulation. For incorporation into other products, add during the cool-down phase at temperatures below 40°C to preserve piperine activity. Can be combined with other actives at 5-15% inclusion rate. When formulating with UV-sensitive ingredients, consider piperine's photo-isomerization potential and add appropriate stabilizers.

Usage rate: As a finished product: apply directly to skin. For formulation: 5-15% in leave-on products for penetration enhancement; 10-20% in targeted treatment products. Clinical studies have used 0.5-1% piperine in final formulations for therapeutic effects. For vitiligo adjunct therapy, final concentration of 1% piperine has shown optimal efficacy with manageable irritation profile.

Product Description: Emulgel™ Piperine addresses multiple skin concerns through scientifically validated mechanisms. Preclinical studies demonstrate significant wound healing acceleration, with 0.5% piperine hydrogels showing comparable efficacy to silver sulfadiazine in closure speed and histological improvement. The formulation shows promise for atopic dermatitis management, with ethosomal piperine preparations reducing inflammatory markers, skin thickness, and IgE levels in animal models. Additionally, piperine exhibits antimicrobial and anti-biofilm properties against common skin pathogens including S. aureus and P. aeruginosa, while recent research suggests potential for sebum regulation through PPARγ pathway modulation, offering benefits for oily skin management.

Solubility: The emulgel system provides excellent compatibility with both hydrophilic and lipophilic ingredients. Piperine itself shows limited water solubility but is readily soluble in alcohol, propylene glycol, and oils. The cyclodextrin complex enhances aqueous dispersibility while maintaining stability. Compatible with most cosmetic solvents and can be incorporated into water-based, oil-based, or emulsion systems.

Storage: Store in a cool, dry place away from direct sunlight. Optimal storage temperature 15-25°C. Protect from light to prevent photo-isomerization of piperine. Keep container tightly closed to prevent moisture absorption. The emulgel maintains stability for 24 months when stored properly. Avoid repeated freeze-thaw cycles which may affect gel structure.

INCI Name: Aqua, Piperine, Propylene Glycol, Cyclodextrin, Caprylic/Capric Triglyceride, Glyceryl Stearate, Phenoxyethanol, Chlorphenesin