Palmitoyl Tripeptide-38

Cosmetics Code: 11117

Palmitoyl Tripeptide-38 is a matrikine-mimetic lipopeptide powder for anti-wrinkle, firmness, and smoother-looking skin formulations. Best suited for leave-on peptide serums, creams, eye care, and neck care products.

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Palmitoyl Tripeptide-38™ is a synthetic matrikine-mimetic lipopeptide supplied as a white to off-white cosmetic powder for leave-on anti-aging formulations.

The ingredient is used to support smoother-looking skin, visible wrinkle care, firmness, and elasticity by targeting extracellular-matrix and dermal-epidermal-junction appearance pathways. It is especially relevant for peptide serums, eye creams, neck creams, and premium facial creams where long skin contact time and mild processing are available.

This SKU is the powder raw material, not a pre-diluted commercial peptide solution. Formulation dosage should therefore be based on this supplied powder form, with typical use around 0.5% and a practical range of 0.1-1.0% in finished cosmetics.

Product Description: Palmitoyl Tripeptide-38 is positioned as a matrix-support peptide for products targeting forehead lines, crow's feet, fine lines, loss of firmness, and uneven skin texture. The palmitoyl chain improves cosmetic affinity compared with the non-lipidated peptide sequence, while the tripeptide sequence is associated with collagen VI / laminin-derived matrikine signaling concepts used in modern anti-aging peptide design.

The most direct public performance data for this ingredient family is mostly from commercial Palmitoyl Tripeptide-38 systems and multi-active finished formulas, not from this powder alone. For customer-facing claims, frame the benefit as cosmetic appearance support: smoother-looking skin, reduced appearance of lines, improved firmness feel, and matrix-support positioning. Avoid therapeutic wording such as dermal regeneration or wound repair.

Evidence / Model Key Endpoints Formulation Implication
Palmitoyl Tripeptide-38 commercial peptide-system data Reported support for collagen I/III/IV, fibronectin, hyaluronic acid, and laminin-5 matrix targets; visible wrinkle smoothing in forehead and crow's feet studies. Use in leave-on anti-wrinkle and firmness products; keep claims cosmetic and appearance-based.
Clinical multi-active formulas containing Palmitoyl Tripeptide-38 Improved wrinkle depth/volume, elasticity, moisture, TEWL, roughness, and brightness in finished-formula studies. Best paired with humectants, barrier-support actives, antioxidants, and well-preserved mild leave-on bases.
Anti-aging peptide review context Matrikine and palmitoylated peptides are established cosmetic approaches for ECM-related anti-aging positioning. Supports peptide-led positioning but final efficacy still depends on formula, dose, stability, and packaging.

Usage: Suitable for leave-on anti-aging serum, peptide serum, facial cream, eye cream, neck cream, firming lotion, wrinkle-care essence, and premium repair-positioned cosmetics.

Mixing method:

- Add during cool-down below 40°C; avoid prolonged heating after peptide addition.

- Pre-disperse or pre-dissolve in a compatible water/glycol premix before adding to the main batch. Confirm clarity and stability in the complete formula.

- Keep final product pH around 4.0-5.5. Avoid high-pH systems, strong oxidizers, and unnecessary high-shear processing after addition.

- Use light-protective or airless packaging when possible and perform accelerated stability, pH drift, viscosity, color/odor, and preservative-challenge checks.

Usage rate: 0.1-1.0% of the finished formula. Typical starting level: 0.5%.

Product characteristics: White to off-white powder.

Solubility: Process as a peptide powder in water/glycol-compatible leave-on systems. Prepare a small premix and verify clarity, pH, and stability in the finished formula; solubility and clarity can vary with electrolyte level, preservative system, and total active load.

Storage: Keep tightly closed, protected from heat, light, moisture, and oxidation.


  • White to off-white powder
  • Room (25-40C)
  • 24 Months from manufacturing or testing date.
  • 0.10% - 1.00%
  • Add into oil phase. Heat tolerant.
  • Avoid heat above 70C
  • 4.00 - 5.50
  • Soluble in Water
  • -
Test Name Specification
Appearance white or almost white powder
Molecular Ion Mass 675.97
Purity (HPLC) NLT 95.0%
Water Content (K.F) NMT 8.0%
Cl- Content (IC) NMT 15.0%

“Review scope: Palmitoyl Tripeptide-38 is described as a Matrixyl synthe’6 peptide associated with ECM components including hyaluronic acid, collagens, laminins, and fibronectin.”
Ferreira MS, Magalhaes MC, Sousa-Lobo JM, Almeida IF Trending Anti-Aging Peptides

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Palmitoyl Tripeptide-38

Palmitoyl Tripeptide-38 is a matrikine-mimetic lipopeptide powder for anti-wrinkle, firmness, and smoother-looking skin formulations. Best suited for leave-on peptide serums, creams, eye care, and neck care products.

Palmitoyl Tripeptide-38™ is a synthetic matrikine-mimetic lipopeptide supplied as a white to off-white cosmetic powder for leave-on anti-aging formulations.

The ingredient is used to support smoother-looking skin, visible wrinkle care, firmness, and elasticity by targeting extracellular-matrix and dermal-epidermal-junction appearance pathways. It is especially relevant for peptide serums, eye creams, neck creams, and premium facial creams where long skin contact time and mild processing are available.

This SKU is the powder raw material, not a pre-diluted commercial peptide solution. Formulation dosage should therefore be based on this supplied powder form, with typical use around 0.5% and a practical range of 0.1-1.0% in finished cosmetics.

Product Description: Palmitoyl Tripeptide-38 is positioned as a matrix-support peptide for products targeting forehead lines, crow's feet, fine lines, loss of firmness, and uneven skin texture. The palmitoyl chain improves cosmetic affinity compared with the non-lipidated peptide sequence, while the tripeptide sequence is associated with collagen VI / laminin-derived matrikine signaling concepts used in modern anti-aging peptide design.

The most direct public performance data for this ingredient family is mostly from commercial Palmitoyl Tripeptide-38 systems and multi-active finished formulas, not from this powder alone. For customer-facing claims, frame the benefit as cosmetic appearance support: smoother-looking skin, reduced appearance of lines, improved firmness feel, and matrix-support positioning. Avoid therapeutic wording such as dermal regeneration or wound repair.

Evidence / Model Key Endpoints Formulation Implication
Palmitoyl Tripeptide-38 commercial peptide-system data Reported support for collagen I/III/IV, fibronectin, hyaluronic acid, and laminin-5 matrix targets; visible wrinkle smoothing in forehead and crow's feet studies. Use in leave-on anti-wrinkle and firmness products; keep claims cosmetic and appearance-based.
Clinical multi-active formulas containing Palmitoyl Tripeptide-38 Improved wrinkle depth/volume, elasticity, moisture, TEWL, roughness, and brightness in finished-formula studies. Best paired with humectants, barrier-support actives, antioxidants, and well-preserved mild leave-on bases.
Anti-aging peptide review context Matrikine and palmitoylated peptides are established cosmetic approaches for ECM-related anti-aging positioning. Supports peptide-led positioning but final efficacy still depends on formula, dose, stability, and packaging.

Usage: Suitable for leave-on anti-aging serum, peptide serum, facial cream, eye cream, neck cream, firming lotion, wrinkle-care essence, and premium repair-positioned cosmetics.

Mixing method:

- Add during cool-down below 40°C; avoid prolonged heating after peptide addition.

- Pre-disperse or pre-dissolve in a compatible water/glycol premix before adding to the main batch. Confirm clarity and stability in the complete formula.

- Keep final product pH around 4.0-5.5. Avoid high-pH systems, strong oxidizers, and unnecessary high-shear processing after addition.

- Use light-protective or airless packaging when possible and perform accelerated stability, pH drift, viscosity, color/odor, and preservative-challenge checks.

Usage rate: 0.1-1.0% of the finished formula. Typical starting level: 0.5%.

Product characteristics: White to off-white powder.

Solubility: Process as a peptide powder in water/glycol-compatible leave-on systems. Prepare a small premix and verify clarity, pH, and stability in the finished formula; solubility and clarity can vary with electrolyte level, preservative system, and total active load.

Storage: Keep tightly closed, protected from heat, light, moisture, and oxidation.

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