“Direct in vitro evidence: Acetyl Tetrapeptide-2 increased HaCaT keratinocyte stiffness, supporting an anti-aging/skin-mechanics benefit direction.”
Acetyl Tetrapeptide-2 (Powder)
Cosmetics
Code: 125423
Acetyl Tetrapeptide-2 powder for firming, anti-sagging, pollution-defense, antioxidant, and tone-evening formulas.
Acetyl Tetrapeptide-2 (Powder) is a peptide powder for firming, anti-sagging, pollution-defense, antioxidant-support, and tone-evening skincare formulas.
This active gives formulators a powerful multi-benefit peptide story: structural protein support for firmer-looking skin, pollution resilience, oxidative-stress care, glycation-related aging support, and visible complexion improvement. The powder format is ideal when the formula team wants to design its own water/polyol carrier, humectant system, preservative system, and delivered peptide level.
Product Description: Acetyl Tetrapeptide-2 is used in Pep®-Neo style concepts for skin firmness and urban-aging protection. Reported development data include up to 2.3-fold FBLN5 increase, 1.7-fold LOXL1 increase, 21.7% elastin increase, and 47.3% collagen I increase in human dermal fibroblasts.
| Benefit area | Positioning for finished formulas |
|---|---|
| Firming / anti-sagging | Supports FBLN5, LOXL1, elastin, and collagen I related firming concepts. |
| Pollution defense | Data describe 69% antioxidant activation, 23% protection against internal pollution, 62% reduction in advanced glycation end-products, 22% reduction in oxidative DNA damage, and 14% reduction in lipid peroxidation under pollution stress. |
| Tone-evening / brightening | Brightening-related testing described 41% melanin reduction, plus 28% lower melanin and 38% smaller dark-spot area within 7 days in an Asian-skin clinical study. |
Usage: Leave-on serums, gels, lotions, and creams for skin firming, anti-sagging, pollution-defense, antioxidant-support, glycation-care, and tone-evening concepts.
Mixing method:
- Pre-dissolve or pre-disperse in a compatible water/polyol phase before adding to the main batch.
- Add during cool-down below 40°C.
- Confirm clarity, pH, preservative compatibility, color, odor, and active stability in the final base.
Usage rate: use by delivered active level. Pep®-Neo style solution contains 0.1% peptide and is used at 2-10%, so the equivalent delivered-active range from pure powder is approximately 0.002-0.01%. Preparing a dilute stock solution first is recommended for accurate dosing.
Product characteristics: white to off-white powder.
Solubility: Pre-dissolve in a compatible water/polyol system before adding to the batch.
Storage: Keep tightly sealed, dry, protected from light and heat. Refrigerated storage is preferred for long-term peptide stability.
INCI Name: Acetyl Tetrapeptide-2
- White to off-white powder
- Room (25-40C)
- 24 Months from manufacturing or testing date.
- 0.00% - 0.00%
- 0.00%
- Add at last step. Avoid temperature above 40C.
- Heat Tolerant
- 0.00 - 0.00
- Soluble in Water
- -
| Test Name | Specification |
|---|---|
| Appearance | white or almost white powder |
| Molecular ion mass | 565.62 |
| Purity (HPLC) | NLT 95.0% |
| Water content (K.F.) | Reported value |
| Chloride content (HPLC) | Reported value |
| Peptide content | Reported value |
“Closest mechanism evidence: LOX/LOXL enzymes are present in human skin and associated with elastic fibers, supporting elastin-assembly targeting; not Acetyl Tetrapeptide-2 specific.”
“Closest mechanism evidence: LOXL stimulation correlated with increased elastin in adult skin, supporting the firmness/elastogenesis pathway claimed for Acetyl Tetrapeptide-2; not peptide-specific.”
“Closest FBLN5-target evidence: fibulin-5 deposition in human skin decreases with aging and UVB exposure, supporting FBLN5 as a relevant skin-aging marker; not Acetyl Tetrapeptide-2 specific.”
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