Acetyl Tetrapeptide-2 (Powder)
Cosmetics
Code: 125423
Powder form of Acetyl Tetrapeptide-2 for firming, anti-sagging, pollution-defense, and skin-brightening formulas.
Acetyl Tetrapeptide-2 is the powder form of the same peptide used in Pep®-Neo, positioned for firming, anti-sagging, pollution-protection, and complexion-brightening cosmetic concepts.
This SKU is intended for formulators who want to build their own solvent, preservative, and humectant system while keeping the same Acetyl Tetrapeptide-2 benefit direction as the liquid solution.
The source efficacy profile describes support for structural protein assembly, antioxidant defense, pollution resilience, and dark-spot reduction. In the matched liquid form, the peptide was reported to increase FBLN5 by up to 2.3-fold and LOXL1 by 1.7-fold, stimulate elastin synthesis by 21.7%, and increase collagen I by 47.3% in human dermal fibroblasts.
Additional source data describes 69% antioxidant activation, 23% protection against internal pollution, 62% reduction in advanced glycation end-products, 22% reduction in oxidative DNA damage, and 14% reduction in lipid peroxidation under pollution stress. Brightening-related testing also described a 41% reduction in melanin, plus 28% lower melanin and 38% smaller dark-spot area within 7 days in a clinical Asian-skin study.
| Focus | How this powder aligns with Pep®-Neo |
|---|---|
| Structural protein support | Acetyl Tetrapeptide-2 supports Fibulin 5 (FBLN5) and LOXL1, two proteins involved in functional elastin assembly and skin firmness. |
| Firmness data | Human dermal fibroblast testing described up to 2.3-fold FBLN5 increase, 1.7-fold LOXL1 increase, 21.7% elastin increase, and 47.3% collagen I increase. |
| Pollution protection | The matched liquid form is positioned to reduce oxidative and pollution-related damage through AHR inhibition and NRF2 activation. |
| Brightening support | Source data also describes reduced melanin and dark-spot appearance, so the powder can be used in firming and tone-evening cosmetic concepts. |
Use: leave-on serums, gels, lotions, and creams for skin-firming, anti-sagging, pollution-defense, and brightening concepts.
How to mix: pre-dissolve or pre-disperse into a compatible water / polyol phase, then add during cool-down. Keep processing temperature below 40 °C and confirm clarity, pH, and stability in the final base.
Utilization rate: use by delivered active level. The matched solution contains 0.1% peptide and is used at 2-10%, so the equivalent delivered-active range from pure powder is approximately 0.002-0.01%. Preparing a dilute stock solution first is recommended for accurate dosing.
Product characteristics: white to off-white powder
Solubility: pre-dissolve in a compatible water / polyol system before adding to the batch
Storage: keep tightly sealed, dry, protected from light and heat. Refrigerated storage is preferred for long-term peptide stability.
INCI Name: Acetyl Tetrapeptide-2
- White to off-white powder
- Room (25-40C)
- 24 Months from manufacturing or testing date.
- 0.00% - 0.00%
- 0.00%
- Add at last step. Avoid temperature above 40C.
- Heat Tolerant
- 0.00 - 0.00
- Soluble in Water
- -
| Test Name | Specification |
|---|---|
| Appearance | white or almost white powder |
| Molecular ion mass | 565.62 |
| Purity (HPLC) | NLT 95.0% |
| Water content (K.F.) | Reported value |
| Chloride content (HPLC) | Reported value |
| Peptide content | Reported value |
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