“KTTKS-family scope: procollagen-derived KTTKS supports ECM protein production in fibroblast-type cells.”
Myristoyl Pentapeptide-4
Cosmetics
Code: 186667
High-purity myristoylated KTTKS cosmetic peptide for anti-aging leave-on formulas, supporting smoother-looking skin, visible firmness, and peptide-based fine-line care.
Myristoyl Pentapeptide-4™ is a high-purity cosmetic signal peptide supplied as a white to off-white powder. It is a myristoylated KTTKS-type lipopeptide, with a myristic-acid chain attached to the Lys-Thr-Thr-Lys-Ser peptide sequence to improve cosmetic handling compared with the non-lipidated peptide.
The strongest public research base is from KTTKS and lipo-KTTKS analogs, especially Palmitoyl Pentapeptide-4 / Pal-KTTKS. These studies support ECM-focused cosmetic positioning: smoother-looking skin, visible fine-line reduction, improved firmness appearance, and peptide support in anti-aging leave-on formulations. Direct clinical data for this exact myristoylated SKU should be treated as limited, so final claims should remain cosmetic and evidence-scoped.
This raw material has HPLC purity NLT 98.0%, molecular ion mass 774.02, acetic acid content NMT 20.0%, and water content NMT 8.0%. Because this is a highly concentrated powder, formulators should dose by ppm or prepare a pre-diluted water/glycol stock for accurate batching.
Product Description: Myristoyl Pentapeptide-4 is suitable for technical peptide systems where long skin contact time is expected: anti-aging serums, eye-area gels, facial creams, hydrogel masks, light lotions, and lash/brow conditioning products. It is best positioned as a skin-conditioning peptide that supports the appearance of smoother, firmer skin rather than as a drug-like growth or tissue-repair active.
| Evidence scope | Key endpoints | Formulation implication |
|---|---|---|
| KTTKS procollagen fragment | KTTKS identified as a minimum type-I-procollagen sequence able to increase type I/III collagen and fibronectin production in fibroblast-type cells. | Mechanistic basis for ECM-support and visible firmness positioning. |
| C16-KTTKS / lipo-KTTKS model | Human dermal and corneal fibroblast work showed concentration-dependent collagen stimulation with lipo-KTTKS peptide amphiphiles. | Supports a cautious analogy for lipidated KTTKS peptides such as myristoylated KTTKS. |
| Pal-KTTKS clinical analog | A 12-week double-blind split-face cosmetic study using 3 ppm Pal-KTTKS reported better fine-line/wrinkle appearance than placebo. | Clinical support is strongest for the palmitoylated analog, so claims for this SKU should remain cosmetic and evidence-scoped. |
| Skin stability/permeation studies | KTTKS and Pal-KTTKS models show peptide stability and skin-layer retention are formulation-dependent. | Use cool-down addition, mild pH, and water/glycol delivery to protect activity and distribution. |
For development work, treat the myristoyl chain as a delivery/compatibility modification, not as proof that the molecule is oil-soluble. The peptide should be protected from high heat, strong acids/alkalis, repeated moisture exposure, and aggressive preservation or surfactant systems that may compromise peptide stability or create eye-area irritation.
Usage: Leave-on anti-aging serum, eye serum, peptide gel, cream/lotion, hydrogel mask, skin-firming product, and lash/brow conditioning serum. Rinse-off formats are possible but inefficient because contact time is short.
Mixing method:
- Pre-dissolve in purified water, water/propanediol, water/butylene glycol, or water/glycerin to make a low-concentration stock solution before final batching.
- Add during cool-down or at the final step when the formula is below 40°C. Avoid hot emulsification, hot-fill processing, and prolonged heating.
- Recommended finished-product pH is 5.0-7.0. Development range may extend to pH 4.5-7.5 if HPLC recovery and stability are confirmed.
- For clear serums and eye/lash products, verify clarity, preservative compatibility, and irritation profile after adding polymers, electrolytes, fragrance, and botanical extracts.
Usage rate: 0.005-0.02% of this high-purity powder (50-200 ppm). For very low-dose facial products, 0.001-0.005% may be evaluated when accurate ppm dosing and assay verification are available.
Product characteristics: White or off-white powder; molecular ion mass 774.02; HPLC purity NLT 98.0%; acetic acid NMT 20.0%; water NMT 8.0%.
Solubility: Soluble in water and glycols; dispersible in cream or gel bases. Do not treat as a normal oil-soluble active despite the myristoyl chain.
Storage: Store tightly closed, protected from moisture. Room-temperature transport at 25°C is acceptable; keep at 2-8°C for long-term storage.
- White to off-white powder
- Fridge (1-10C)
- 24 Months from manufacturing or testing date.
- 0.01% - 0.02%
- 0.01%
- Add at last step. Avoid temperature above 40C.
- Heat Tolerant
- 5.00 - 7.00
- Soluble in Water, Soluble in glycols, Dispersible in cream or gel base
- Anti-Aging Ingredient, Serum, Cream, Clear Gel, Hair Treatment
- -
| Test Name | Specification |
|---|---|
| Appearance | White or off-white powder |
| Molecular Ion Mass | 774.02 |
| Purity (HPLC) | NLT 98.0% |
| Acetic acid Content (HPLC) | NMT 20.0% |
| Water Content (K.F) | NMT 8.0% |
| Storage | Store at 25°C for transportation; Store at 2°C to 8°C for long term storage. |
“Lipo-KTTKS analog scope: C16-KTTKS stimulated collagen production in human dermal and corneal fibroblasts.”
“Pal-KTTKS clinical analog: 3 ppm Pal-KTTKS improved fine-line/wrinkle appearance versus placebo.”
“Delivery/stability analog: KTTKS and Pal-KTTKS skin stability/permeation data inform topical peptide formulation.”
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