CycloRetinol (Heterophyllin B, Pure Peptide) is a pure cyclic octapeptide active associated with Pseudostellaria heterophylla, positioned for soothing, oxidative-stress support, and conservative brightening concepts in topical skincare.

The strongest independent evidence for purified Heterophyllin B is preclinical rather than clinical. In LPS-stimulated RAW264.7 macrophages it reduced nitric oxide, IL-1beta, IL-6, ROS, and apoptosis, which supports calm-skin and stress-recovery positioning. Early literature also suggests preliminary tyrosinase modulation, but the evidence is still too limited for aggressive whitening claims.

The CycloRetinol name can support a retinol-alternative conversation, but the current independent literature for purified Heterophyllin B does not justify strong retinoid-equivalence claims. At molecular weight 778.9, passive penetration through intact stratum corneum should also be treated conservatively, so formulation design and delivery strategy matter.

Product Description: Purified Heterophyllin B is most suitable for formulators building high-value peptide systems for stressed-skin care, barrier-support concepts, recovery-oriented gels or masks, and gentle well-aging formulas. The available data support anti-inflammatory and antioxidant-stress moderation most directly. Non-skin studies suggest broader homeostasis support, but those should be treated as mechanistic support rather than direct topical proof. Supplier-led extract dossiers around HB-standardized materials discuss firmer retinol-alternative and procollagen positioning, but those data should not be transferred directly to neat HB powder without separate substantiation.

Usage: Soothing serums, gel-creams for stressed or sensitivity-prone skin, barrier-support creams, conservative brightening serums, and hydrogel or mask systems for recovery-support concepts.

Mixing method:

- Dissolve in the water phase or in a small buffered water concentrate at room temperature, then add during final processing. Avoid prolonged exposure above 40°C.

- Keep the finished formula in a mild buffered range, ideally around pH 4.5-6.5. Avoid strong acids, strong alkalinity, and unnecessary oxidizing stress until real stability data are available.

- For emulsions, pre-dissolve in the aqueous phase before emulsification or post-add into the water phase during cool-down. For gels and serums, confirm clarity and preservative compatibility.

- If stronger delivery is desired, pair with suitable carrier engineering such as liposomal or vesicular systems rather than assuming deep passive penetration from a simple solution.

Usage rate: 0.01-0.10%

Typical pilot work can start around 0.03-0.05% in leave-on systems. Because this SKU is a pure peptide, the ingredient percentage equals delivered active percentage in the finished formula.

Product characteristics: White to off-white powder; low-odor to odorless peptide material.

Solubility: Soluble in water or buffered aqueous concentrates. Not intended for direct oil-phase dissolution.

Storage: Store tightly closed under dry, refrigerated conditions away from heat, light, and unnecessary moisture exposure.