“Direct Tetrapeptide-21/GEKG evidence: boosted extracellular-matrix formation in vitro and showed clinical anti-wrinkle benefit in vivo.”
Tetrapeptide-21 (Powder)
Cosmetics
Code: 6888
Tetrapeptide-21 powder for ECM-support, firming, wrinkle-care, neck cream, serum, gel, and anti-aging formulas.
Tetrapeptide-21 (Powder) is a cosmetic peptide powder for extracellular-matrix support, firming, and visible wrinkle-care formulas.
Tetrapeptide-21 is used in advanced anti-aging products that target the balance between ECM synthesis and ECM degradation. This makes it a strong fit for formulas positioned around smoother-looking skin, better firmness, and refined facial or neck wrinkles.
Product Description: This powder lets formulators build a custom Tetrapeptide-21 premix for serums, gels, creams, and leave-on anti-aging systems. It is a good choice when a formula needs an ECM-focused peptide story with full control over carrier, preservative system, and delivered peptide level.
| Formula story | Recommended positioning |
|---|---|
| ECM support | Supports formulas focused on extracellular matrix synthesis/degradation balance. |
| Wrinkle-care | Useful for anti-wrinkle and firming formulas for face, neck, and targeted mature-skin areas. |
| Premium comparison | Research positioning describes better wrinkle-reduction efficiency than Matrixyl in the cited context. |
Usage: Anti-wrinkle serums, firming gels, neck creams, face creams, leave-on ECM-support products, and multi-peptide anti-aging systems.
Mixing method:
- Pre-dissolve in a small compatible water/glycol phase before adding to the main batch.
- Add during cool-down, preferably below 40°C, and avoid prolonged heat exposure.
- Confirm clarity, preservative compatibility, final pH, and peptide stability before scale-up.
Usage rate: typically 0.001-0.01% active powder. Prepare a stock solution when needed and dose to match the selected delivered Tetrapeptide-21 target, including 2000ppm solution-style targets where appropriate.
Product characteristics: white powder.
Solubility: Pre-dissolve in water/glycol phase; add during cool-down and avoid heat.
Storage: Keep tightly closed, dry, protected from light and heat. Refrigerated storage is preferred for long-term peptide stability.
- White powder
- Room (25-40C)
- 24 Months from manufacturing or testing date.
- 0.10% - 2.00%
- 1.00%
- Add into oil phase. Heat tolerant.
- Avoid heat above 80C
- 4.00 - 7.00
- Soluble in Water
- -
| Test Name | Specification |
|---|---|
| Appearance | White or off-white powder |
| Molecular Ion Mass | 388.42 |
| Purity (HPLC) | NLT 95.0% |
| Acetic acid Content (HPLC) | Reported value |
| Water Content (K.F) | NMT 8.0% |
| Storage | Store at 25°C for transportation; Store at 2°C to 8°C. |
“Review evidence: GEKG/Tetrapeptide-21 is described as a matrikine used for skin rejuvenation through dermal extracellular-matrix support.”
“Closest peptide-family evidence: topical peptide complex improved anti-wrinkle outcomes by stimulating basement-membrane protein expression, supporting the anti-aging peptide mechanism category.”
“Review evidence: commercially used cosmetic peptides, including ECM-inspired matrikines, are reviewed for collagen, hyaluronic-acid, and anti-aging bioactivity evidence.”
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