“Direct DABBA/SYN-AKE evidence: a 4% formulation containing 2500 ppm Dipeptide Diaminobutyroyl Benzylamide Diacetate significantly reduced glabellar expression-wrinkle area and length versus placebo after 4 weeks.”
Syn-Ake Peptide Powder
Cosmetics
Code: 7285
Syn-Ake style Dipeptide Diaminobutyroyl Benzylamide Diacetate powder for expression-line and wrinkle-smoothing formulas.
Syn-Ake Peptide Powder is Dipeptide Diaminobutyroyl Benzylamide Diacetate in powder form for expression-line and wrinkle-smoothing cosmetic formulas.
Syn-Ake style peptides are inspired by Waglerin-1 and are used in products that target the look of wrinkles related to repeated facial movement. This makes the active highly suitable for forehead lines, eye-area expression lines, smile lines, firming gels, and fast-smoothing anti-wrinkle products.
Product Description: Use this powder when you want to build your own high-performance Syn-Ake style serum, gel, or cream with full control over the carrier, preservative system, pH, and delivered active level. The product is best prepared as a controlled water/glycol premix before final addition.
| Formula goal | Recommended positioning |
|---|---|
| Expression-line care | Targets the appearance of lines linked with repeated facial expression and muscle-contraction concepts. |
| Fast visible smoothing | Use in products positioned for visible wrinkle softening within about 3 hours in a suitable finished formula. |
| Formula control | Best in water/glycol premixes with final formula pH 3.5-6.5 and validated preservative compatibility. |
Usage: Expression-line serums, firming gels, anti-wrinkle creams, forehead products, eye-area products, and targeted peptide boosters.
Mixing method:
- Pre-dissolve in a small compatible water/glycol phase before adding to the main batch.
- Add during cool-down, preferably below 40°C, and avoid prolonged heat exposure.
- Final formula pH 3.5-6.5 is preferred.
- Avoid potassium sorbate and benzoic acid type conflicts unless stability and performance are revalidated.
- Check final pH, clarity, odor, color, and active stability before scale-up.
Usage rate: typically 0.0025-0.02% active powder. Do not exceed the equivalent active level without irritation and stability testing.
Product characteristics: white to off-white peptide powder.
Solubility: Pre-dissolve in water/glycol premix; final formula pH 3.5-6.5 is preferred.
Storage: Keep tightly closed, dry, protected from light and heat. Refrigerated storage is preferred for long-term peptide stability.
- White to off-white powder
- Room (25-40C)
- 24 Months from manufacturing or testing date.
- 0.10% - 1.00%
- 0.50%
- Add into oil phase. Heat tolerant.
- Heat Tolerant
- 0.00 - 0.00
- Soluble in Water
“Cosmetic-peptide review scope: neurotransmitter-inhibiting peptides, including SYN-AKE-type peptides, are recognized among cosmetic peptide mechanisms, but the review emphasizes variable evidence levels across peptides and test models.”
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