“Mechanistic support for progerin-focused anti-aging: progerin production increases during cellular senescence in normal human fibroblasts, supporting progerin as a relevant anti-aging target, not direct evidence for Trifluoroacetyl Tripeptide-2.”
Trifluoroacetyl Tripeptide-2 (Powder)
Cosmetics
Code: 8937
Trifluoroacetyl Tripeptide-2 powder for progerin-focused anti-aging, firmness, wrinkle-care, and age-support formulas.
Trifluoroacetyl Tripeptide-2 (Powder) is a peptide powder for progerin-focused anti-aging, firming, and age-support cosmetic formulas.
Trifluoroacetyl Tripeptide-2 is used in advanced well-aging products because research around this peptide describes reduction of progerin synthesis in skin fibroblast cells. That makes it a strong active story for brands targeting firmness loss, visible wrinkles, and mature-skin resilience.
Product Description: Use this powder to prepare a precise low-dose premix for serums, lotions, creams, eye products, and other leave-on anti-aging formulas. It is best suited for high-value formulations where a progerin-focused peptide claim can differentiate the product from standard collagen-only peptide systems.
| Formula direction | Recommended positioning |
|---|---|
| Progerin-focused aging | Builds a differentiated anti-aging story around visible skin aging and cellular-aging concepts. |
| Firmness and wrinkles | Suitable for firming creams, wrinkle-care serums, eye-area products, and mature-skin leave-on products. |
| Precise dosing | Very low delivered-active levels are typical; use a dilute stock solution for accurate manufacturing. |
Usage: Anti-wrinkle lotions, firming creams, eye serums, face serums, mature-skin products, and age-support leave-on formulas.
Mixing method:
- Prepare a dilute water/glycol stock solution for accurate dosing.
- Add during cool-down, preferably below 40°C, and avoid prolonged heat exposure.
- Check final pH, clarity, odor, color, and active stability before scale-up.
Usage rate: typically 0.0001-0.001% active powder. Calculate by delivered peptide level and validate performance, stability, and skin compatibility in the finished formula.
Product characteristics: white to off-white peptide powder.
Solubility: Pre-dissolve in water/glycol phase; add at final stage and avoid heat.
Storage: Keep tightly closed, dry, protected from light and heat. Refrigerated storage is preferred for long-term peptide stability.
- White to off-white powder
- Room (25-40C)
- 24 Months from manufacturing or testing date.
- 0.10% - 1.00%
- 0.50%
- Add into oil phase. Heat tolerant.
- Heat Tolerant
- 0.00 - 0.00
- Soluble in Water
- -
| Test Name | Specification |
|---|---|
| Appearance | White or almost white powder |
| Water Content (Karl Fischer) | ≤ 8.0% |
| Peptide Purity (By HPLC) | ≥ 95.0% |
“Mechanistic skin-aging support: lamin A/progerin-related nuclear defects are observed in human aging models, supporting the biological rationale for progerin-modulating anti-aging concepts, not direct evidence for Trifluoroacetyl Tripeptide-2.”
“Ingredient-family evidence: a 2025 review of cosmetic bioactive peptides discusses anti-aging peptide mechanisms such as collagen support, fibroblast senescence modulation and extracellular-matrix effects; this is peptide-family evidence rather than exact Trifluoroacetyl Tripeptide-2 clinical proof.”
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