S-()-Camptothecin
97%
- Product Code: 127032
Alias:
Camptothecin; 4-Ethyl-4-hydroxy-1H-pyran[3',4':6,7]indolizine[1,2]quinoline-3,14(4H,12H)-dione
CAS:
7689-03-4
| Molecular Weight: | 348.35 g./mol | Molecular Formula: | C₂₀H₁₆N₂O₄ |
|---|---|---|---|
| EC Number: | MDL Number: | MFCD00081076 | |
| Melting Point: | 260 °C (dec.)(lit.) | Boiling Point: | |
| Density: | Storage Condition: | 2~8°C |
Product Description:
S-()-Camptothecin is primarily used in cancer treatment due to its potent antitumor properties. It works by inhibiting the enzyme topoisomerase I, which is crucial for DNA replication in cancer cells. This inhibition leads to DNA damage and ultimately induces apoptosis in the cancerous cells. It serves as a precursor for the synthesis of other chemotherapeutic agents like topotecan and irinotecan, which are FDA-approved drugs for treating various cancers, including ovarian, colorectal, and small cell lung cancer. Additionally, it is being studied for its potential in combination therapies to enhance efficacy and reduce drug resistance in oncology.
Product Specification:
| Test | Specification |
|---|---|
| Purity (HPLC) | 97-100 |
| Specific Rotation [A]20/D (C=0.4, CHCL3:Methanol=8:2) | 37-42 |
| Appearance | Light Yellow To Brown Powder Or Crystals Or Solid |
| Solubility In CHCL3:MEOH (4:1) | Clear To Slightly Hazy, 5 Mg/Ml |
Sizes / Availability / Pricing:
| Size (g) | Availability | Price | Quantity |
|---|---|---|---|
| 0.100 | 10-20 days | $12.60 |
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| 0.500 | 10-20 days | $26.40 |
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| 1.000 | 10-20 days | $40.80 |
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| 5.000 | 10-20 days | $138.01 |
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| 25.000 | 10-20 days | $483.05 |
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S-()-Camptothecin
S-()-Camptothecin is primarily used in cancer treatment due to its potent antitumor properties. It works by inhibiting the enzyme topoisomerase I, which is crucial for DNA replication in cancer cells. This inhibition leads to DNA damage and ultimately induces apoptosis in the cancerous cells. It serves as a precursor for the synthesis of other chemotherapeutic agents like topotecan and irinotecan, which are FDA-approved drugs for treating various cancers, including ovarian, colorectal, and small cell lung cancer. Additionally, it is being studied for its potential in combination therapies to enhance efficacy and reduce drug resistance in oncology.
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