(S)-()-Camptothecin
≥99%(HPLC)
- Product Code: 127033
Alias:
Camptothecin; 4-Ethyl-4-hydroxy-1H-pyran[3',4':6,7]indolizine[1,2]quinoline-3,14(4H,12H)-dione
CAS:
7689-03-4
| Molecular Weight: | 348.35 g./mol | Molecular Formula: | C₂₀H₁₆N₂O₄ |
|---|---|---|---|
| EC Number: | MDL Number: | MFCD00081076 | |
| Melting Point: | 260 °C (dec.)(lit.) | Boiling Point: | |
| Density: | Storage Condition: | 2~8°C |
Product Description:
Used primarily in cancer treatment, it inhibits the enzyme topoisomerase I, which is crucial for DNA replication in cancer cells. This action leads to the interruption of DNA synthesis and induces apoptosis in malignant cells. It serves as a key precursor for synthesizing more potent chemotherapeutic agents like irinotecan and topotecan, which are FDA-approved for treating colorectal and ovarian cancers, respectively. Additionally, ongoing research explores its potential in combating other diseases, including viral infections and autoimmune disorders, due to its mechanism of action on cellular DNA processes.
Product Specification:
| Test | Specification |
|---|---|
| Purity (%) | 99-100 |
| Appearance | Light Yellow To Brown Powder Or Crystals Or Solid |
Sizes / Availability / Pricing:
| Size (g) | Availability | Price | Quantity |
|---|---|---|---|
| 0.100 | 10-20 days | £40.26 |
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| 1.000 | 10-20 days | £90.24 |
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| 5.000 | 10-20 days | £290.85 |
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(S)-()-Camptothecin
Used primarily in cancer treatment, it inhibits the enzyme topoisomerase I, which is crucial for DNA replication in cancer cells. This action leads to the interruption of DNA synthesis and induces apoptosis in malignant cells. It serves as a key precursor for synthesizing more potent chemotherapeutic agents like irinotecan and topotecan, which are FDA-approved for treating colorectal and ovarian cancers, respectively. Additionally, ongoing research explores its potential in combating other diseases, including viral infections and autoimmune disorders, due to its mechanism of action on cellular DNA processes.
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