Tolbutamide
10mM in DMSO
Reagent
Code: #239115
CAS Number
64-77-7
blur_circular Chemical Specifications
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Molecular Information
Weight
270.35 g/mol
Formula
C₁₂H₁₈N₂O₃S
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Registry Numbers
MDL Number
MFCD00027169
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Storage & Handling
Storage
-20°C
description Product Description
Used primarily in the management of type 2 diabetes mellitus, this compound helps control blood glucose levels by stimulating insulin release from the pancreas. It belongs to the sulfonylurea class of drugs, which act by closing ATP-sensitive potassium channels in pancreatic beta cells, leading to cell depolarization and subsequent insulin secretion. It is typically prescribed when diet and exercise alone are insufficient for glucose control. Due to its moderate duration of action, it is often taken one to two times daily. It may also be used off-label in certain cases of neonatal diabetes caused by specific genetic mutations affecting potassium channels. Its use requires monitoring for hypoglycemia, especially in elderly patients or those with irregular meal patterns.
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