2-(2,6-Dioxopiperidin-3-yl)isoindoline-1,3-dione
10mM in DMSO
Reagent
Code: #239123
Alias
Reaction stops; thalidomide
CAS Number
50-35-1
blur_circular Chemical Specifications
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Molecular Information
Weight
258.23 g/mol
Formula
C₁₃H₁₀N₂O₄
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Registry Numbers
MDL Number
MFCD00153873
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Storage & Handling
Storage
-20°C
description Product Description
Widely used in pharmaceutical research, this compound serves as a key intermediate in the synthesis of immunomodulatory drugs. It is particularly important in the development of cereblon E3 ligase modulators, which are a class of therapeutics used in treating multiple myeloma and other hematological cancers. Its structure enables selective protein degradation through the ubiquitin-proteasome system, making it valuable in targeted cancer therapy. Additionally, it is used in the design of small-molecule drugs that can recruit specific disease-causing proteins for degradation. Due to its role in enhancing drug specificity and efficacy, it is a critical scaffold in modern drug discovery, especially in oncology and inflammatory disease research.
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