Drospirenone is primarily used as a key active ingredient in oral contraceptives, effectively preventing pregnancy by inhibiting ovulation, altering the cervical mucus, and changing the endometrium. It is also utilized in hormone replacement therapy (HRT) to alleviate symptoms of menopause, such as hot flashes and vaginal dryness, by balancing estrogen levels. Additionally, it is prescribed for the treatment of premenstrual dysphoric disorder (PMDD), helping to reduce emotional and physical symptoms associated with the condition. In some cases, it is used to manage acne in women by regulating hormone-related skin issues. Its anti-mineralocorticoid properties make it beneficial in reducing water retention and bloating, often associated with hormonal fluctuations.