(4R,5R,6S)-4-Nitrobenzyl 3-((diphenoxyphosphoryl)oxy)-6-((R)-1-hydroxyethyl)-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate
97%
Reagent
Code: #230131
CAS Number
90776-59-3
science Other reagents with same CAS 90776-59-3
blur_circular Chemical Specifications
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Molecular Information
Weight
594.51 g/mol
Formula
C₂₉H₂₇N₂O₁₀P
thermostat
Physical Properties
Melting Point
129-131°C
Boiling Point
722.4°C
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Storage & Handling
Storage
Room temperature, dry
description Product Description
Used as a key intermediate in the synthesis of beta-lactam antibiotics, particularly in the preparation of carbapenem-class antimicrobial agents. Its structure allows for selective functionalization at multiple sites, making it valuable in constructing complex antibiotic molecules with enhanced stability and broad-spectrum activity. The diphenoxyphosphoryl group acts as a protecting and activating moiety during coupling reactions, while the nitrobenzyl group enables photolytic or reductive deprotection under mild conditions. This compound is instrumental in solid-phase and solution-phase peptide coupling strategies aimed at developing new-generation antibiotics with resistance to beta-lactamase degradation.
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