Used in chemotherapy to treat various types of cancer, including leukemia, lymphoma, and certain solid tumors. It works by inhibiting cell division through disruption of microtubule formation in the mitotic spindle, effectively stopping the growth of rapidly dividing cancer cells. Commonly included in combination therapy regimens due to its potent antimitotic activity. Administered intravenously under strict medical supervision because of its toxicity and potential side effects, particularly neurotoxicity. Also used in pediatric oncology, especially for childhood acute lymphoblastic leukemia.