Dienestrol is primarily used in hormone replacement therapy (HRT) to alleviate symptoms associated with menopause, such as hot flashes, vaginal dryness, and atrophy. It helps restore estrogen levels in women who have low or imbalanced hormones. Additionally, it is applied topically in the form of creams or suppositories to treat vulvar and vaginal atrophy, improving the health and elasticity of vaginal tissues. In some cases, it has been used to manage certain hormonal imbalances or conditions related to estrogen deficiency. However, its use is carefully monitored due to potential risks associated with estrogen therapy, such as increased chances of certain cancers or cardiovascular issues.