Distearoyl phosphatidylcholine is widely used in the formulation of liposomes for drug delivery systems. Its ability to form stable lipid bilayers makes it ideal for encapsulating therapeutic agents, ensuring controlled release and targeted delivery to specific tissues or cells.

In the cosmetics industry, it serves as an emulsifier and moisturizer in skincare products, enhancing texture and providing hydration by forming a protective barrier on the skin.

It is also utilized in research as a model membrane component to study lipid-protein interactions and membrane dynamics. Additionally, it finds application in the food industry as an emulsifying agent to improve the stability and texture of various products.