VU0155069 is primarily used in research settings to study the role of phospholipase D (PLD) in cellular processes. It acts as a selective inhibitor of PLD1, making it a valuable tool for investigating the enzyme's function in signal transduction, membrane trafficking, and cell proliferation. Researchers utilize it to explore its potential therapeutic applications in diseases where PLD1 activity is implicated, such as cancer, inflammation, and neurodegenerative disorders. Its specificity helps in understanding the distinct roles of PLD1 and PLD2 in cellular mechanisms, aiding in the development of targeted treatments.