Used as a key reagent in organic synthesis for the phosphorylation of alcohols, amines, and thiols, enabling the formation of phosphate esters, amides, and thioesters. It plays a significant role in the production of flame retardants, plasticizers, and agrochemicals. In peptide chemistry, it facilitates the activation of carboxylic acids for peptide bond formation. Additionally, it is employed in the synthesis of organophosphorus compounds, which are utilized in various industrial and pharmaceutical applications. Its reactivity with nucleophiles makes it valuable for modifying biomolecules and developing advanced materials.