Celastrol is widely studied for its potent anti-inflammatory and antioxidant properties. It has shown promise in research related to autoimmune diseases such as rheumatoid arthritis, where it helps reduce joint inflammation and tissue damage. It is also being investigated for its potential in treating neurodegenerative disorders like Alzheimer’s and Parkinson’s disease due to its ability to protect nerve cells and reduce brain inflammation. In cancer research, celastrol demonstrates the ability to inhibit tumor growth and induce apoptosis in various cancer cell lines, including prostate, breast, and liver cancers. It interferes with multiple signaling pathways involved in cell proliferation and survival, particularly the NF-κB pathway. Additionally, celastrol has been explored for its role in obesity and metabolic disorders. It enhances leptin sensitivity and improves insulin signaling, which may help in managing weight and glucose metabolism. Due to these diverse biological activities, celastrol is considered a valuable compound in developing therapies for chronic inflammatory and age-related diseases.