PIK-75 free base is primarily utilized in biochemical research as a potent and selective inhibitor of the enzyme PI3K (phosphoinositide 3-kinase), specifically targeting the p110α isoform. Its application is significant in studying cellular signaling pathways, particularly those involved in cell growth, proliferation, and survival. Researchers employ PIK-75 free base to investigate the role of PI3K in various diseases, including cancer, where aberrant PI3K signaling is often implicated. It is also used in preclinical studies to evaluate the therapeutic potential of PI3K inhibition in oncology. Additionally, PIK-75 free base serves as a valuable tool in elucidating the molecular mechanisms of PI3K-related pathways and in the development of targeted therapies.