Prostratin is a naturally occurring phorbol ester (12-deoxyphorbol 13-acetate) derived from the bark of the mamala tree (Homalanthus nutans). It is primarily studied for its potential in medical research, particularly in the treatment of HIV/AIDS. It has shown promise in activating latent HIV reservoirs, making the virus susceptible to antiretroviral therapies. This could be a significant step toward a functional cure for HIV. Additionally, it is being explored for its ability to stimulate the immune system, which may have applications in treating other viral infections or immune-related conditions. Prostratin is also of interest in cancer research due to its potential to induce cell differentiation, which could help in developing therapies for certain types of cancer. Its natural origin has sparked interest in ethnopharmacology and traditional medicine studies.