“Direct human NAFLD evidence: 200 mg/day naringenin for 4 weeks improved serum TG, TC, LDL, HDL and hepatic steatosis grade in overweight/obese NAFLD patients; not specific to the commercial water-dispersible grade.”
MultiCare™ Grapefruit Extract (Naringenin 20%, Water-Dispersible)
Food
Code: 254245
Water-dispersible grapefruit extract with 20% naringenin. Enhanced dispersion/apparent solubility helps improve absorption opportunity and efficacy potential versus conventional grapefruit extract powder.
MultiCare™ Grapefruit Extract (Naringenin 20%, Water-Dispersible) provides approximately 20% naringenin in a water-dispersible grapefruit extract powder for capsules, tablets, sachets, powdered drinks and functional beverages. Naringenin is a citrus flavanone found naturally in grapefruit and related citrus fruits. Standard naringenin-rich extracts are poorly water-soluble, which can limit dispersion in beverage systems and limit the fraction that is available for absorption after ingestion. This water-dispersible grade is designed to increase apparent solubility and dispersion in gastrointestinal fluid; for a poorly soluble flavonoid such as naringenin, better dispersion can support higher absorption opportunity and therefore better efficacy potential at the same delivered active amount.
| Benefit | Typical study dose* | Key findings | High-quality sources |
|---|---|---|---|
| 1 Solubility and bioavailability support | Technology studies commonly use naringenin with cyclodextrin-type carriers to increase soluble fraction before oral delivery. | Cyclodextrin complexation has been reported to greatly increase naringenin aqueous solubility and improve oral exposure in preclinical models. This supports the formulation support for a water-dispersible naringenin extract. | Naringenin bioavailability study |
| 2 Vascular and antioxidant support from grapefruit flavanones | Human grapefruit-flavanone studies typically use daily grapefruit juice or citrus-flavanone preparations for weeks to months. | A randomized crossover trial in postmenopausal women reported vascular stiffness benefits from grapefruit flavanone intake, while citrus polyphenol supplement trials show signals on cardiovascular-risk biomarkers. These data support use as citrus-flavanone antioxidant support, within dietary-support claims, not disease treatment. | Grapefruit flavanone RCT |
| 3 Cardiometabolic research context | Dietary polyphenol and citrus-flavanone studies vary widely by extract, dose and population. | Human and preclinical literature on citrus flavanones links naringenin-family ingredients with antioxidant, lipid metabolism and inflammatory-marker pathways. Direct clinical evidence for isolated naringenin is still limited, so claims should remain supportive and structure/function oriented. | Citrus polyphenol supplement trial |
*For this 20% raw material, 250-1,000 mg/day supplies approximately 50-200 mg/day naringenin. Example: 500 mg/day raw material supplies about 100 mg/day naringenin. Final serving size should be selected according to the finished product claim, local regulations and total formula design.
Mechanistic highlights
- Bioavailability-first design: Naringenin is hydrophobic and disperses poorly in water. Improving apparent solubility helps the active release from the dosage form, stay dispersed in gastrointestinal fluid and become more available for absorption.
- Antioxidant signaling: Citrus flavanones are studied for antioxidant and redox-signaling effects. This supports formulas aimed at oxidative-stress balance and healthy aging use.
- Vascular and metabolic pathways: Naringenin-family research includes lipid metabolism, endothelial function, inflammatory signaling and insulin-sensitivity pathways. Human evidence is supportive but not definitive for isolated naringenin.
- Formulation advantage: Compared with conventional grapefruit extract, the water-dispersible format is easier to use in powders and beverages and may provide better in-body efficacy potential because a larger fraction of the active can be dispersed before absorption.
Safety & practical use
- Suggested raw-material range: 250-1,000 mg/day, equivalent to about 50-200 mg/day naringenin.
- Applications: capsules, tablets, sachets, powdered drinks, functional beverages and antioxidant supplement blends.
- Drug-interaction caution: Grapefruit-derived flavonoids can interact with drug-metabolism pathways. Consumers using prescription medicines, especially narrow-therapeutic-index drugs, should seek professional medical advice before use.
- Best use: Position as antioxidant, citrus-flavanone and bioavailability-enhanced dietary support. Do not present as treatment or prevention of disease.
- very pale cream to pale yellow water-dispersible powder
- Room (25-40C)
- 24 Months from manufacturing or testing date. (Current Lot will expire: 02/2028)
- 250mg - 1000mg
- 500mg
- 250mg - 1000mg
- 500mg
- Powder mixing for food/beverage (oil‑phase disperse or glycol premix)
- Heat Tolerant
- 3.00 - 8.00
- Dispersible in water, Dispersible in powder
- Powdered Foods, Beverages, Nutrient Supplement, Dietary Supplement, Beverage Ingredient
- -
| Test Name | Specification |
|---|---|
| Appearance | Light yellow to off-white powder |
| Content of Naringenin | 19-21% |
| Loss on Drying | ≤14.0% |
| Residue on Ignition | ≤0.1% |
| Lead (Pb) | ≤2.0 mg/kg |
| Arsenic (As) | ≤3.0 mg/kg |
“Direct human NAFLD evidence: naringenin supplementation reduced atherogenic lipid ratios, non-HDL-C, BMI and visceral fat level in overweight/obese NAFLD patients; not specific to the commercial water-dispersible grade.”
“Human pharmacokinetic support: oral naringenin doses of 150-900 mg were safe in healthy adults and produced dose-related serum exposure; supports oral supplement feasibility but not the exact commercial material.”
“Formulation-bioavailability support: naringenin complexation with hydroxypropyl-β-cyclodextrin greatly increased aqueous solubility and improved oral exposure in preclinical testing; closest evidence for water-dispersible naringenin rationale, not the exact commercial material.”
“Ingredient-family human evidence: grapefruit juice flavanones were linked with vasculoprotective nutrigenomic changes related to inflammation, cell interaction and vascular function in postmenopausal women; evidence is for grapefruit flavanones, not isolated naringenin extract.”
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